ADVANCED AND CLINICAL IMMUNOLOGY; CASE STUDY ON ALLERGY Essay

ADVANCED AND CLINICAL IMMUNOLOGY; CASE STUDY ON ALLERGY - Essay Example However, the most common protein causing milk allergy is alpha S1-casein. Others may me caseins and whey. In case of egg allergy, the most common allergen is ovomucoid while others present in egg white are ovalbumin, ovotransferrin, and lysozyme. The egg yolk also contains some allergens that start an antibody reaction and among the most common are apovitillin, livetin and vosvetin. In case of peanut allergy the mostly common allergen found is a Lupine which is a legume and causes severe allergy in patients sensitive to it. 4. Th-2 like cells can be identified in the peripheral blood and lesions of atopic-dermatitis patients producing IL-4, 5, 13 and also IL-17 from Th17 cells. Explain the role(s) of these cytokines in allergy (10 Marks). The Th2 response is characterized by the release of several interleukins that ultimately goes through a chain of responses that leads to ‘humoral immunity’ by neutralizinge the non-cytolytic antibodies. The Th2-type cytokines include Interleukins 4, 5 and 13. IL 4, 5 and 13 are linked with the support of IgE and eosinophilic response in atopy. Other than this IL-17 has more of anti-inflammatory effect. Therefore, Th2 finds to be counteracting the Th1 medicated microbial action and thus produces a well balanced response to an immune attack (BMJ 2000). At homeostasis, Mast cells are the important cells that are present not only in skin but also in mucosal tissues. Both mast cells and quantity of eosinophils in mucosa are related to hyperactivity of lungs. There are several studies that suggest a correlation between mast cells and eosinophills that at some extent related to Eosinophil Cationic protein release. On stimulation, mast cells release IL-5 and PAF to enhance Eosinophil Cationic Protein (ECP) release from eosinophils. Since the number of mast cells is elevated in Asthmatic patients thus this assay is quite helpful in finding the allergic reaction. Hygiene Hypothesis suggests that the